Fig. 1 · Structure
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LEQ803
Metabolite of Ribociclib
LEQ803 (N-Desmethyl Ribociclib) is a metabolite of the CDK4/6 inhibitor Ribociclib, generated through the metabolism by CYP3A4. This compound exhibits significant biological activity in inhibiting cyclin-dependent kinases 4 and 6, making it relevant for research in cancer biology. Its potential applications include studying efficacy and resistance mechanisms in oncology and exploring therapeutic strategies targeting the cell cycle.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1211441-59-6 |
| Applications | Metabolite of Ribociclib |
| Formula | C22H28N8O |
| Molecular Weight | 420.51 |
| Synonyms | N-Desmethyl Ribociclib |
| SMILES | O=C(C1=CC2=C(N1C3CCCC3)N=C(NC4=NC=C(N5CCNCC5)C=C4)N=C2)NC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.