Fig. 1 · Structure
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Leramistat
Mitochondrial Complex 1 Inhibitor
Leramistat is a selective inhibitor of mitochondrial complex I, impacting cellular metabolism and immune regulation. It effectively inhibits ATP production in THP-1 human monocytes, exhibiting an IC50 of 0.63 μM. Leramistat has demonstrated potential in the research of atopic dermatitis, autoimmune diseases, inflammatory disorders, and various cancers, and it may also play a role in inhibiting osteoclast-mediated pathologies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1642602-54-7 |
| Applications | Mitochondrial Complex 1 Inhibitor |
| Formula | C20H21ClN2O3S |
| Molecular Weight | 404.91 |
| Synonyms | HMC-C-01-A; MBS2320 |
| SMILES | N#CC1=C(C2=CC=C(C=C2)S(N[C@H]3CC[C@](O)(CC3)C)(=O)=O)C=CC(Cl)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.