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Biological Activity
Lesinurad is a selective uric acid re-absorption inhibitor (SURI) and is also a selective inhibitor of URAT1, a transporter in the kidney that regulates uric acid excretion from the body.
Targets
| URAT1 | ||||
| In vitro | DMSO | 72 mg/mL (178.09 mM) | |
| Water | Insoluble | ||
| Ethanol | 49 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.74 mL | 123.68 mL | 247.35 mL |
| 0.5 mM | 4.95 mL | 24.74 mL | 49.47 mL |
| 1 mM | 2.47 mL | 12.37 mL | 24.74 mL |
| 5 mM | 0.49 mL | 2.47 mL | 4.95 mL |
*The above data is based on the productmolecular weight 404.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12981 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 878672-00-5 |
| Formula | C17H14BrN3O2S |
| M. Wt | 404.28 |
| Purity | >98% |
| Synonyms | RDEA594, RDEA 594, RDEA-594 |
| SMILES | C1CC1C2=CC=C(C3=CC=CC=C23)N4C(=NN=C4Br)SCC(=O)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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