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Fig. 1 · Structure
Cat. No.
A12981
CAS No.
878672-00-5
Formula
C17H14BrN3O2S
Mol. Weight
404.28

Documents & Downloads

Lesinurad

Cat. No. A12981 CAS 878672-00-5

SUR inhibitor

Lesinurad is a selective uric acid re-absorption inhibitor (SURI) and is also a selective inhibitor of URAT1, a transporter in the kidney that regulates uric acid excretion from the body.

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For laboratory research use only. We do not sell to patients.

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Biological Activity

Target & Activity

Target Activity Value
URAT1

Cellular Effect

Cell Line Activity Value Description Reference
HEK293 IC50 15.1 μM Inhibition of human URAT1 expressed in HEK293 cells assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric acid addition measured after 10 mins by liquid scintillation counting method [PMID: 28337320]
HEK293 IC50 2.03 μM Inhibition of human OAT4 expressed in HEK293 cells by assessed as [14C]urate uptake preincubated for 5 mins followed by [14C]urate addition and measured after 10 mins by liquid scintillation counting method [PMID: 31774679]
HEK293 IC50 4.4 μM Inhibition of human URAT1 expressed in HEK293 cells assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric acid addition measured after 10 mins by liquid scintillation counting method [PMID: 28337320]
HEK293 IC50 7.3 μM Inhibition of human URAT1 expressed in HEK293 cells assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric acid addition measured after 10 mins by liquid scintillation counting method [PMID: 28337320]

Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 878672-00-5
Applications SUR inhibitor
Formula C17H14BrN3O2S
Molecular Weight 404.28
Synonyms RDEA594
SMILES
C1CC1C2=CC=C(C3=CC=CC=C23)N4C(=NN=C4Br)SCC(=O)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

SolventReported Solubility
DMSO 72 mg/mL (178.09 mM)
Water Insoluble
Ethanol 49 mg/mL

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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