Fig. 1 · Structure
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Levoketoconazole
Ketoconazole Enantiomer
Levoketoconazole is the 2S,4R enantiomer of ketoconazole, functioning primarily as a potent inhibitor of cortisol synthesis. By specifically inhibiting enzymes such as CYP11B1, CYP11A1, and CYP17A1, Levoketoconazole effectively reduces the production of cortisol and testosterone. This compound is particularly relevant for research applications focusing on endogenous Cushing’s syndrome and related endocrine disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 142128-57-2 |
| Applications | Ketoconazole Enantiomer |
| Formula | C26H28Cl2N4O4 |
| Molecular Weight | 531.43 |
| Synonyms | (-)-Ketoconazole; (-)-Ketoconazol; (-)-R 41400 |
| SMILES | CC(N1CCN(C2=CC=C(OC[C@H]3O[C@](CN4C=CN=C4)(C5=CC=C(Cl)C=C5Cl)OC3)C=C2)CC1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.