Fig. 1 · Structure
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Levoleucovorin
Drug Derivative
Levoleucovorin, a levoisomer of folinic acid, primarily acts as a drug derivative to inhibit the enzyme LOXL2 with an IC50 of 68.81 μM. Its biologically active properties include the inhibition of cancer cell proliferation and migration, as well as induction of apoptosis. Levoleucovorin is also utilized as a rescue agent for high-dose methotrexate therapy and shows potential in reducing embryonic malformations. This compound is valuable for research in oncology and endocrinology, particularly in studies focused on breast cancer and osteosarcoma.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 68538-85-2 |
| Applications | Drug Derivative |
| Formula | C20H23N7O7 |
| Molecular Weight | 473.44 |
| Synonyms | Levofolinic acid; Levofolene |
| SMILES | O=CN1C2=C(NC(N)=NC2=O)NC[C@@H]1CNC3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.