Fig. 1 · Structure
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Levomequitazine
Inverse H4 Receptor Agonist
Levomequitazine, an inverse agonist of the human histamine H4 receptor, exhibits strong binding affinity with an IC50 of 94 nM for hM2 and 17 nM for hM3. This compound effectively antagonizes the actions of histamine at the H4 receptor, leading to significant anti-inflammatory effects. Levomequitazine is suitable for research applications focused on inflammatory diseases, providing a valuable tool for exploring therapeutic strategies targeting the H4 receptor in various pathological conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inverse Agonist |
| CAS Number | 88598-74-7 |
| Applications | Inverse H4 Receptor Agonist |
| Formula | C20H22N2S |
| Molecular Weight | 322.47 |
| Synonyms | (S)-Mequitazine |
| SMILES | N1(C2=CC=CC=C2SC3=CC=CC=C31)C[C@H]4C5CCN(CC5)C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.