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LGX 818 (Encorafenib)

Selective B-RAF Inhibitor

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Catalog No. A13226

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
LGX 818 1mg A13226-1
LGX 818 5mg A13226-5
LGX 818 10mg A13226-10
LGX 818 25mg A13226-25
LGX 818 10mM * 1mL in DMSO A13226-10mM-D

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

LGX818 is an orally available Raf kinase inhibitor with potential antineoplastic activity.

LGX 818 (Encorafenib)

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Publications citing Adooq Products
LGX 818 (Encorafenib) Citations (1)
  • Seidel D, .et al. A multidimensional impedance platform for the real-time analysis of single and combination drug pharmacology in patient-derived viable melanoma models, Biosens Bioelectron, 2019, Jan 1;123:185-194 PMID: 30201332

Chemical Information

Catalog Num A13226
Actions Inhibitor
M. Wt 540.01
Formula C22H27ClFN7O4S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1269440-17-6, 1269440-29-0
Synonyms LGX818, LGX-818
SMILES C[[email protected]@H](CNC1=NC=CC(=N1)C2=CN(N=C2C3=CC(=CC(=C3F)NS(=O)(=O)C)Cl)C(C)C)NC(=O)OC

Biological Activity

LGX818 is an orally available Raf kinase inhibitor with potential antineoplastic activity.
B-Raf (V600E)
4 nM(EC50)


Solubility (25°C)* In vitro DMSO 100 mg/mL (185.18 mM)
Water <1 mg/mL (<1 mM)
Ethanol 100 mg/mL (185.18 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.52 mL 92.59 mL 185.18mL
0.5 mM 3.7 mL 18.52 mL 37.04 mL
1 mM 1.85 mL 9.26 mL 18.52 mL
5 mM 0.37 mL 1.85 mL 3.7 mL

*The above data is based on the productmolecular weight 540.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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