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LGX 818 (Encorafenib)

LGX 818 (Encorafenib)

Name: LGX 818 (Encorafenib)
Brand: Adooq Bioscience
SKU: A13226
Rating: 100 (1 reviews)

Catalog No.: A13226

Selective B-RAF Inhibitor

Product Citations (1)

LGX 818 (Encorafenib) Chemical Structure

CAS NO. 1269440-17-6, 1269440-29-0

LGX818 is an orally available Raf kinase inhibitor with potential antineoplastic activity.

Availability: In stock

Package	Price	Qty
1 mg	$50.00
5 mg	$90.00
10 mg	$120.00
25 mg	$190.00
10mM * 1mL in DMSO	$110.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq LGX 818 (Encorafenib)

Seidel D, .et al. A multidimensional impedance platform for the real-time analysis of single and combination drug pharmacology in patient-derived viable melanoma models, Biosens Bioelectron, 2019, Jan 1;123:185-194 PMID: 30201332

Biological Activity

LGX818 is an orally available Raf kinase inhibitor with potential antineoplastic activity.

Targets

B-Raf (V600E)
4 nM(EC50)

Solubility *

In vitro	DMSO	93 mg/mL (172.22 mM)
	Water	Insoluble
	Ethanol	93 mg/mL (172.22 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.52 mL	92.59 mL	185.18 mL
0.5 mM	3.7 mL	18.52 mL	37.04 mL
1 mM	1.85 mL	9.26 mL	18.52 mL
5 mM	0.37 mL	1.85 mL	3.7 mL

*The above data is based on the productmolecular weight 540.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A13226
Actions	Inhibitor
CAS No.	1269440-17-6, 1269440-29-0
Formula	C22H27ClFN7O4S
M. Wt	540.01
Purity	>98%
Synonyms	LGX818, LGX-818
SMILES	C[[email protected]@H](CNC1=NC=CC(=N1)C2=CN(N=C2C3=CC(=CC(=C3F)NS(=O)(=O)C)Cl)C(C)C)NC(=O)OC
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.