Total item
Cart Subtotal
$0.00 - Seidel D, .et al. A multidimensional impedance platform for the real-time analysis of single and combination drug pharmacology in patient-derived viable melanoma models, Biosens Bioelectron, 2019, Jan 1;123:185-194 PMID: 30201332
Biological Activity
LGX818 is an orally available Raf kinase inhibitor with potential antineoplastic activity.
Targets
| B-Raf (V600E) | ||||
| 4 nM(EC50) |
| In vitro | DMSO | 100 mg/mL (185.18 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 100 mg/mL (185.18 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.52 mL | 92.59 mL | 185.18 mL |
| 0.5 mM | 3.7 mL | 18.52 mL | 37.04 mL |
| 1 mM | 1.85 mL | 9.26 mL | 18.52 mL |
| 5 mM | 0.37 mL | 1.85 mL | 3.7 mL |
*The above data is based on the productmolecular weight 540.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13226 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 540.01 |
| Formula | C22H27ClFN7O4S |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1269440-17-6, 1269440-29-0 |
| Synonyms | LGX818, LGX-818 |
| SMILES | C[[email protected]@H](CNC1=NC=CC(=N1)C2=CN(N=C2C3=CC(=CC(=C3F)NS(=O)(=O)C)Cl)C(C)C)NC(=O)OC |
Datasheet
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
Regorafenib (BAY 73-4506)
Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. Regorafenib (BAY 73-4506) is an ora…
TAK-632
TAK-632 is a potent pan-RAF inhibitor with favorable in vitro activity (BRAF(V600E) IC50, 2.4 nM; BRAF(wt), 8.3 nM; CRAF, 1.4 nM; pMEK (A3…
ZM 336372
ZM 336372 is a potent ATP-competitive inhibitor of Raf-1 in vitro (IC50 = 70 nM) with the paradoxical effect of inducing >100-fold activatio…
Dabigatran ethyl ester
Dabigatran ethyl ester, which is an emerging oral anticoagulant which is a direct inhibitor of thrombin activity.
Diazepinomicin
Diazepinomicin, also known as TLN-4601, is a small-molecule inhibitor of the RAS/RAF/MAPK signaling pathway with potential antineoplastic ac…
AZ628
AZ628 is a RAF inhibitor with IC50 values: ca 30 nM for BRAF V600E and wild-type CRAF and 100 nM for wild-type BRAF.
B-Raf-inhibitor 1
B-Raf inhibitor 1 is a potent and selective B-Raf inhibitor with cell IC50s of 0.31 uM and 2 nM for A375 proliferation and A375 p-ERK respec…
MLN2480 (BIIB-024)
MLN 2480 is an oral, selective pan-Raf kinase inhibitor in chinical trials.
Keywords:buy LGX 818 (Encorafenib) | LGX 818 (Encorafenib) Supplier | purchase | cost | manufacturer | order | distributor | buy 1269440-17-6, 1269440-29-0| 1269440-17-6, 1269440-29-0 Supplier | purchase 1269440-17-6, 1269440-29-0 | 1269440-17-6, 1269440-29-0 cost | 1269440-17-6, 1269440-29-0 manufacturer | order 1269440-17-6, 1269440-29-0 | 1269440-17-6, 1269440-29-0 distributor
Adooq Quality Guarantee
We promise all products perform as described.