LGX 818 (Encorafenib)

Catalog No.: A13226

Selective B-RAF Inhibitor

LGX 818 (Encorafenib) Chemical Structure

CAS NO. 1269440-17-6, 1269440-29-0

LGX818 is an orally available Raf kinase inhibitor with potential antineoplastic activity.

Availability: In stock

Package Price Qty
1 mg
$45.00
5 mg
$80.00
10 mg
$110.00
25 mg
$170.00
10mM * 1mL in DMSO
$110.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

LGX818 is an orally available Raf kinase inhibitor with potential antineoplastic activity.
Targets
B-Raf (V600E)
4 nM(EC50)
In vitro DMSO 100 mg/mL (185.18 mM)
Water <1 mg/mL (<1 mM)
Ethanol 100 mg/mL (185.18 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.52 mL 92.59 mL 185.18 mL
0.5 mM 3.7 mL 18.52 mL 37.04 mL
1 mM 1.85 mL 9.26 mL 18.52 mL
5 mM 0.37 mL 1.85 mL 3.7 mL

*The above data is based on the productmolecular weight 540.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13226
Actions Inhibitor
M. Wt 540.01
Formula C22H27ClFN7O4S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1269440-17-6, 1269440-29-0
Synonyms LGX818, LGX-818
SMILES C[[email protected]@H](CNC1=NC=CC(=N1)C2=CN(N=C2C3=CC(=CC(=C3F)NS(=O)(=O)C)Cl)C(C)C)NC(=O)OC

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