LH1307

Catalog No.: A35695
Inhibitor of PD-1/PD-L1 Protein-Protein Interaction
LH1307 is a C2-symmetric inhibitor of the PD-1/PD-L1 protein-protein interaction, exhibiting an IC50 value of 3.0 μM. This compound serves as a valuable tool for cancer research, enabling the exploration of immunotherapeutic strategies targeting the PD-1/PD-L1 axis. Its application can facilitate studies on immune evasion mechanisms in tumors and the development of novel cancer therapies.
Grouped product items
Size Price Stock Qty
1mg
$160.00
In stock
5mg
$445.00
In stock
10mg
$2,165.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionLH1307 is a C2-symmetric inhibitor of the PD-1/PD-L1 protein-protein interaction, exhibiting an IC50 value of 3.0 μM. This compound serves as a valuable tool for cancer research, enabling the exploration of immunotherapeutic strategies targeting the PD-1/PD-L1 axis. Its application can facilitate studies on immune evasion mechanisms in tumors and the development of novel cancer therapies.
Product Information
Catalog NumA35695
FormulaC54H58N8O6
Molecular Weight915.09
CAS Number2375720-38-8
SMILESN#CC1=CN=CC(COC2=CC(OCC3=CC=CC(C4=CC=CC(COC5=C(C)C=C(CNCCNC(C)=O)C(OCC6=CC(C#N)=CN=C6)=C5)=C4C)=C3C)=C(C)C=C2CNCCNC(C)=O)=C1
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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