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LH1307

Inhibitor of PD-1/PD-L1 Protein-Protein Interaction

LH1307 is a C2-symmetric inhibitor of the PD-1/PD-L1 protein-protein interaction, exhibiting an IC50 value of 3.0 μM. This compound serves as a valuable tool for cancer research, enabling the exploration of immunotherapeutic strategies targeting the PD-1/PD-L1 axis. Its application can facilitate studies on immune evasion mechanisms in tumors and the development of novel cancer therapies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2375720-38-8
Applications	Inhibitor of PD-1/PD-L1 Protein-Protein Interaction
Formula	C₅₄H₅₈N₈O₆
Molecular Weight	915.09
SMILES	N#CC1=CN=CC(COC2=CC(OCC3=CC=CC(C4=CC=CC(COC5=C(C)C=C(CNCCNC(C)=O)C(OCC6=CC(C#N)=CN=C6)=C5)=C4C)=C3C)=C(C)C=C2CNCCNC(C)=O)=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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LH1307

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LH1307 1 mg