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Liarozole fumarate

Cytochrome P450

Liarozole fumarate is an imidazole derivative that serves as a potent inhibitor of cytochrome P450-dependent all-trans retinoic acid 4-hydroxylase. By inhibiting this enzyme, Liarozole fumarate effectively increases the levels of all-trans retinoic acid in plasma and skin. This compound is primarily utilized in research applications focused on retinoid metabolism and its implications in dermatological studies and cancer therapies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	145858-52-2
Applications	Cytochrome P450
Formula	C₁₇H₁₃ClN₄.3/2C₄H₄O₄
Molecular Weight	482.88
Synonyms	R75251 fumarate
SMILES	ClC1=CC=CC(C(N2C=CN=C2)C3=CC4=C(NC=N4)C=C3)=C1.OC(/C=C/C(O)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.