Fig. 1 · Structure
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Liarozole hydrochloride
RAMBA
Liarozole hydrochloride is an imidazole derivative that functions as a retinoic acid metabolism-blocking agent (RAMBA) by inhibiting the cytochrome P450 (CYP26)-dependent 4-hydroxylation of retinoic acid, with an IC50 of 7 μM. This inhibition leads to elevated tissue concentrations of retinoic acid, which is associated with its antitumoral properties. Liarozole hydrochloride is utilized in research applications focusing on cancer biology and the modulation of retinoic acid signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 145858-50-0 |
| Applications | RAMBA |
| Formula | C17H14Cl2N4 |
| Molecular Weight | 345.23 |
| Synonyms | R75251 hydrochloride |
| SMILES | ClC1=CC(C(C2=CC=C3N=CNC3=C2)N4C=CN=C4)=CC=C1.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.