Fig. 1 · Structure
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Licochalcone A
UGTs inhibitor
Licochalcone A is a flavonoid that acts as an inhibitor of UDP-glucuronosyltransferases (UGTs). It demonstrates significant anti-cancer properties and exhibits broad-spectrum inhibition against multiple UGT isoforms, including UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A9, and 2B7, with IC50 and Ki values below 5 μM. This compound is a valuable tool for research applications focused on drug metabolism and the modulation of glucuronidation pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 58749-22-7 |
| Applications | UGTs inhibitor |
| Formula | C21H22O4 |
| Molecular Weight | 338.40 |
| SMILES | O=C(C1=CC=C(O)C=C1)/C=C/C2=CC(C(C)(C)C=C)=C(O)C=C2OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.