Lifitegrast-d6 is a deuterium-labeled variant of Lifitegrast, functioning as a potent integrin antagonist. It specifically interferes with the interaction between intercellular adhesion molecule 1 (ICAM-1) and lymphocyte function-associated antigen 1 (LFA-1), disrupting the T cell-mediated inflammatory response. With an IC50 value of 2.98 nM, Lifitegrast effectively inhibits Jurkat T cell attachment to ICAM-1. This reagent is ideal for studies focused on dry eye disease and related inflammation pathways.
Lifitegrast-d6 is a deuterium-labeled variant of Lifitegrast, functioning as a potent integrin antagonist. It specifically interferes with the interaction between intercellular adhesion molecule 1 (ICAM-1) and lymphocyte function-associated antigen 1 (LFA-1), disrupting the T cell-mediated inflammatory response. With an IC50 value of 2.98 nM, Lifitegrast effectively inhibits Jurkat T cell attachment to ICAM-1. This reagent is ideal for studies focused on dry eye disease and related inflammation pathways.
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