Lifitegrast

Catalog No.: A17299

LFA-1 antagonist

Lifitegrast

Lifitegrast Chemical Structure

CAS NO. 1025967-78-5

Lifitegrast (SAR 1118) is an integrin lymphocyte function-associated antigen-1 (LFA-1) antagonist; inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM.

Availability: In stock

Package Price Qty
5 mg
$110.00
10 mg
$59.00
50 mg
$177.00
100 mg
$295.00
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Biological Activity

Lifitegrast (SAR 1118) is an integrin lymphocyte function-associated antigen-1 (LFA-1) antagonist; inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM.
In vitro DMSO 98 mg/mL (159.22 mM)
Water Insoluble
Ethanol 20 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.25 mL 81.24 mL 162.48 mL
0.5 mM 3.25 mL 16.25 mL 32.5 mL
1 mM 1.62 mL 8.12 mL 16.25 mL
5 mM 0.32 mL 1.62 mL 3.25 mL

*The above data is based on the productmolecular weight 615.478. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A17299
Actions Antagonist
CAS No. 1025967-78-5
Formula C29H24Cl2N2O7S
M. Wt 615.478
Solubility DMSO
Purity >98%
Synonyms SAR-1118; SAR 1118; SAR1118; Lifitegrast, brand name: Xiidra.
SMILES O=C(O)[[email protected]@H](NC(C1=C(Cl)C2=C(CN(C(C3=CC=C4C=COC4=C3)=O)CC2)C=C1Cl)=O)CC5=CC=CC(S(=O)(C)=O)=C5
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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