Fig. 1 · Structure
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Linsidomine hydrochloride
ROS/RNS Inducer
Linsidomine hydrochloride is a spontaneous generator of reactive oxygen and nitrogen species (ROS/RNS) and a peroxynitrite donor. This compound acts as a vasodilator and inhibits platelet aggregation, making it valuable in cardiovascular research. Linsidomine hydrochloride induces oxidative stress, leading to apoptosis and necrosis in chondrocytes, while also suppressing the migration, proliferation, and neointima formation of vascular smooth muscle cells through the downregulation of annexin A2. Additionally, at low concentrations, it demonstrates protective effects on nerve cells subjected to zinc treatment.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 16142-27-1 |
| Applications | ROS/RNS Inducer |
| Formula | C6H11ClN4O2 |
| Molecular Weight | 206.63 |
| Synonyms | SIN-1 chloride |
| SMILES | NC1=C[N+](N2CCOCC2)=NO1.[Cl-] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.