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Lipid X

LPS Antagonist

Lipid X is a 2,3-diacylglucosamine-1-phosphate that acts as a lipopolysaccharide (LPS) antagonist. It demonstrates notable protective effects by inhibiting the production of tumor necrosis factor, reducing monocyte procoagulant activity, and mitigating neutrophil priming. This reagent has applications in researching Gram-negative bacterial sepsis, endotoxemia, and associated pulmonary hypertension, while exhibiting low toxicity and no in vitro antibacterial activity. Additionally, Lipid X has been observed to reduce mortality rates in models of Gram-negative infections and endotoxin exposure, indicating its potential therapeutic relevance in inflammatory contexts.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	86559-73-1
Applications	LPS Antagonist
Formula	C₃₄H₆₆NO₁₂P
Molecular Weight	711.86
SMILES	O[C@H]1[C@H](OC(C[C@H](O)CCCCCCCCCCC)=O)[C@@H](NC(C[C@H](O)CCCCCCCCCCC)=O)[C@@H](OP(O)(O)=O)O[C@@H]1CO

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.