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Lirentelimab
Lirentelimab (AK002) is a humanized IgG1 monoclonal antibody specifically designed to target sialic acid-binding Ig-like lectin 8 (SIGLEC8). This antibody promotes apoptosis in interleukin-5 (IL-5)-activated eosinophils and effectively inhibits immunoglobulin E (IgE)-mediated mast cell activation. Lirentelimab is primarily utilized in research focused on eosinophilic gastritis and duodenitis, providing a valuable tool for investigating the pathophysiology and potential therapeutic interventions for these conditions.
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Product Details
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2283348-97-8 |
| Molecular Weight | 145000 |
| Synonyms | AK002; Antolimab |
Storage
Store lyophilized at -20°C, keep desiccated.
In lyophilized form, the antibody is stable for 36 months.
After reconstitution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.