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Biological Activity
Lixivaptan (VPA-985, WAY-VPA 985) is an orally active and selective vasopressin receptor V2 antagonist, with IC50 values of 1.2 and 2.3 nM for human and rat V2, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.1 mL | 105.5 mL | 211 mL |
| 0.5 mM | 4.22 mL | 21.1 mL | 42.2 mL |
| 1 mM | 2.11 mL | 10.55 mL | 21.1 mL |
| 5 mM | 0.42 mL | 2.11 mL | 4.22 mL |
*The above data is based on the productmolecular weight 473.93. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21279 |
|---|---|
| Actions | Antagonist |
| CAS No. | 168079-32-1 |
| Formula | C27H21ClFN3O2 |
| M. Wt | 473.93 |
| Purity | >98% |
| Synonyms | VPA-985; WAY-VPA 985 |
| SMILES | O=C(C1=C(Cl)C=C(NC(C2=CC(F)=CC=C2C)=O)C=C1)N(C3)C4=CC=CC=C4CN5C3=CC=C5 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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