Fig. 1 · Structure
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LK-2
ASIC1a Antagonist
LK-2 is an antagonist of the Acid-Sensing Ion Channel 1a (ASIC1a), exhibiting a Kd of 1.9 µM. This compound effectively reduces glutamate-induced enhancement of ASIC1a currents with an IC50 value of 6.6 µM. In preclinical studies, LK-2 demonstrates neuroprotective effects in an ischemic stroke model in mice, enhancing motor function and coordination. Furthermore, LK-2 is capable of penetrating the blood-brain barrier, making it a valuable tool for neuroscience research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 2649762-09-2 |
| Applications | ASIC1a Antagonist |
| Formula | C12H17N2O5P |
| Molecular Weight | 300.25 |
| SMILES | OP(C(C1=CC=CC=C1)N2CC(C(O)=O)NCC2)(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.