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LLW-018

PD-1/PD-L1 Inhibitor

LLW-018 is a potent inhibitor of the PD-1/PD-L1 interaction, demonstrating an IC50 value of 2.61 nM. This compound effectively disrupts the PD-1/PD-L1 pathway, showing an IC50 of 0.88 μM in cell-based assays. LLW-018 holds significant potential for applications in immunotherapy research, particularly in the development of cancer treatments that target immune checkpoint pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3049369-11-8
Applications	PD-1/PD-L1 Inhibitor
Formula	C₃₅H₃₈Cl₂N₄O₅S
Molecular Weight	697.67
SMILES	OCC(CO)NCC1=CC=C(NC2=NSC3=C2C=CC=C3C4=C(C)C(COC5=C(Cl)C=C(CNC(CO)CO)C=C5)=CC=C4)C(Cl)=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.