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LM-030

KLK7/Elastase Inhibitor

LM-030 is a cyclic depsipeptide that functions as a potent inhibitor of kallikrein-related peptidase 7 (KLK7) and human neutrophil elastase, exhibiting IC50 values of 1 nM and 10 nM, respectively. This compound serves as a valuable tool for investigating the pathophysiology of Netherton syndrome and potentially related disorders in skin inflammation. Its high specificity and potency make LM-030 an important reagent for research in protease inhibition and therapeutic applications.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1122484-55-2
Applications	KLK7/Elastase Inhibitor
Formula	C₄₆H₇₂N₈O₁₂
Molecular Weight	929.11
Synonyms	BPR277
SMILES	[C@@H](CC)(C)[C@@]1(N2C(=O)[C@@](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC([C@@H](NC(C(C)C)=O)CCC(N)=O)=O)[C@@H](C)OC(=O)[C@]([C@H](CC)C)(NC(=O)[C@H](CC3=CC=C(O)C=C3)N(C)C1=O)[H])(CC[C@H]2O)[H])[H]

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.