Fig. 1 · Structure
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LMP517
TOP1/2 Inhibitor
LMP517 (NSC 781517) is a potent dual inhibitor of Topoisomerase I and II (TOP1 and TOP2). This compound effectively induces the formation of TOP1 and TOP2 cleavage complexes, leading to DNA damage in cancer cells and increased γH2AX production. LMP517 is useful in cancer research, particularly in studies involving small cell lung cancer, offering insights into the mechanisms of action for therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1883730-99-1 |
| Applications | TOP1/2 Inhibitor |
| Formula | C22H19FN2O5 |
| Molecular Weight | 410.40 |
| Synonyms | NSC 781517 |
| SMILES | O=C1C2=CC3=C(C=C2C4=C1C5=C(C(N4CCCNCCO)=O)C=C(F)C=C5)OCO3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.