Fig. 1 · Structure
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LMTK3-IN-1
LMTK3 Inhibitor
LMTK3-IN-1 is an ATP-competitive inhibitor of lemur tyrosine kinase 3 (LMTK3) with a Kd of 2.5 μM, functioning primarily through the ubiquitin-proteasome pathway to degrade LMTK3. This reagent demonstrates significant anticancer activity across various cancer cell lines and in vivo breast cancer mouse models. LMTK3-IN-1 effectively induces apoptosis in breast cancer cell lines at concentrations ranging from 10 to 20 μM, making it a valuable tool for research in cancer therapeutics.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2764850-23-7 |
| Applications | LMTK3 Inhibitor |
| Formula | C18H11F3N4O |
| Molecular Weight | 356.30 |
| SMILES | FC(F)(OC1=CC=CC(C2=CN=C3C=CC(C4=CC=NC=C4)=NN32)=C1)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.