Fig. 1 · Structure
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LNP Lipid-8
Ionizable Lipid
LNP Lipid-8 is an ionizable single-tail multi-head lipid designed for the development of lipid nanoparticles (LNPs) to facilitate targeted delivery of siRNA to T cells, particularly CD8+ T cells, without the need for additional targeting ligands. This reagent efficiently utilizes endogenous lipid transport pathways to enable cellular uptake and subsequent RNA release via endocytosis, resulting in effective gene silencing. In preclinical studies, LNP Lipid-8 demonstrated significant GFP gene silencing in mouse models while exhibiting favorable efficacy and safety profiles, with minimal hepatic toxicity. This product is suitable for research applications in tumor immunotherapy and T cell-mediated autoimmune disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2408140-60-1 |
| Applications | Ionizable Lipid |
| Formula | C42H71NO7 |
| Molecular Weight | 702.02 |
| SMILES | CCN(CC)CCCOC(OCC(COC(CCCCCCC/C=C\C/C=C\CCCCC)=O)COC(C[C@@]12CC3C[C@H](C[C@@H](C3)C2)C1)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.