Fig. 1 · Structure
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Lobaric acid
TMV Inhibitor
Lobaric acid is a depsipeptide metabolite that functions as an inhibitor of tobacco mosaic virus (TMV). This compound exhibits significant antioxidant, antiproliferative, and enzyme inhibitory properties, demonstrating an IC50 of 97.9 μM in scavenging superoxide free radicals and an EC50 range of 15.2-63.9 μg/mL in inhibiting cancer cell proliferation across various types, including leukemia and solid tumors. Furthermore, Lobaric acid effectively inhibits protein tyrosine phosphatase 1B (PTP1B) with an IC50 of 0.87 μM and reduces the production of 12(S)-HETE by 12(S)-lipoxygenase (IC50=28.5 μM), highlighting its broad potential for research in cancer and virology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 522-53-2 |
| Applications | TMV Inhibitor |
| Formula | C25H28O8 |
| Molecular Weight | 456.49 |
| SMILES | O=C(C1=C(O)C=C(C(OC2=CC(OC)=CC(C(CCCC)=O)=C23)=C1CCCCC)OC3=O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.