Fig. 1 · Structure
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Lobelanidine
nAChR Antagonist
Lobelanidine is a selective antagonist of nicotinic acetylcholine receptors (nAChR), effectively inhibiting the α7 nAChR response as well as the α3β2/α3β4 nAChR responses, with IC50 values of 2.8 μM and 8.2 μM, respectively. This compound serves as a valuable tool for investigating the role of nAChRs in neuronal signaling and various neurological disorders. Its pharmacological properties make it suitable for research applications in neurobiology, drug discovery, and toxicology studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 552-72-7 |
| Applications | nAChR Antagonist |
| Formula | C22H29NO2 |
| Molecular Weight | 339.47 |
| SMILES | OC(CC1N(C(CCC1)CC(O)C2=CC=CC=C2)C)C3=CC=CC=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.