Fig. 1 · Structure
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Lofepramine
Tricyclic Antidepressant
Lofepramine is a tricyclic antidepressant that primarily inhibits the reuptake of noradrenaline and serotonin, with IC50 values of 2.7 μM and 11 μM, respectively. Its mechanism promotes noradrenergic neurotransmission, enhancing serotonergic activity by preventing the uptake of serotonin and modulating tryptophan pyrrolase. Lofepramine also displays notable anxiolytic properties, making it valuable in the study of mood disorders and anxiety-related conditions. This compound is suitable for research applications focusing on the pharmacological mechanisms of antidepressants.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 23047-25-8 |
| Applications | Tricyclic Antidepressant |
| Formula | C26H27ClN2O |
| Molecular Weight | 418.96 |
| Synonyms | Lopramine |
| SMILES | CN(CC(C1=CC=C(Cl)C=C1)=O)CCCN2C3=CC=CC=C3CCC4=CC=CC=C42 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.