Fig. 1 · Structure
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Lonodelestat
hNE Inhibitor
Lonodelestat is a selective, orally active peptide inhibitor of human neutrophil elastase (hNE). This compound exhibits significant potential for the study of cystic fibrosis (CF) by modulating the activity of hNE, a key enzyme implicated in inflammatory responses and tissue damage in CF patients. It serves as a valuable tool for investigating therapeutic strategies aimed at mitigating the effects of excessive neutrophil activity in pulmonary diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 906547-89-5 |
| Applications | hNE Inhibitor |
| Formula | C71H111N15O19 |
| Molecular Weight | 1478.73 |
| Synonyms | POL6014 |
| SMILES | [H][C@@]12CCCN1C(=O)[C@@]1([H])CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@]1([H])CCCN1C(=O)[C@]1([H])CCCN1C(=O)[C@@]([H])(NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@]([H])(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCCCCC)NC2=O)[C@@H](C)O)[C@@H](C)CC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.