Fig. 1 · Structure
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Losartan-d4
Deuterated Losartan
Losartan-d4 is a deuterated form of Losartan, a potent antagonist of the angiotensin II receptor. It effectively competes with angiotensin II for binding to AT1 receptors, exhibiting an IC50 value of 20 nM. This reagent is valuable in pharmacokinetic studies and research focused on cardiovascular diseases, allowing for enhanced tracking and analysis of drug metabolism and receptor interactions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1030937-27-9 |
| Applications | Deuterated Losartan |
| Formula | C22H19D4ClN6O |
| Molecular Weight | 426.94 |
| Synonyms | DuP-753 d4 |
| SMILES | OCC1=C(Cl)N=C(CCCC)N1CC2=C([2H])C([2H])=C(C3=CC=CC=C3C4=NNN=N4)C([2H])=C2[2H] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.