Fig. 1 · Structure
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LP-922056
Notum Pectinacetylesterase Inhibitor
LP-922056 is a potent inhibitor of Notum pectinacetylesterase, exhibiting EC50 values of 21 nM and 55 nM in human and mouse cellular assays, respectively. This compound demonstrates significant biological activity by enhancing midshaft femur cortical bone thickness in both mice and rats. LP-922056 can be utilized in research focused on bone metabolism and the regulation of Wnt signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1365060-22-5 |
| Applications | Notum Pectinacetylesterase Inhibitor |
| Formula | C11H9ClN2O2S2 |
| Molecular Weight | 300.78 |
| SMILES | O=C(O)CSC1=C2C(C(C3CC3)=C(Cl)S2)=NC=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.