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LP23

PD-1/PD-L1 Inhibitor

LP23 is a potent non-arylmethylamine inhibitor of the PD-1/PD-L1 axis, exhibiting an IC50 of 16.7 nM. It effectively restores immune cell function in HepG2 and Jurkat T cell assays and promotes cell death in HepG2 cancer cells. In vivo studies demonstrate its significant anti-tumor activity in the B16-F10 tumor model, achieving a tumor growth inhibition of 88.6% at a dose of 30 mg/kg. This compound serves as a valuable tool for cancer immunotherapy research and the investigation of immune checkpoint pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3008239-25-3
Applications	PD-1/PD-L1 Inhibitor
Formula	C₂₇H₂₇N₃O₅S
Molecular Weight	505.59
SMILES	O=C([C@@H](NCC1=CC(CSC2=NN=C(COC3=C(C)C(C4=CC=CC=C4)=CC=C3)O2)=CC=C1)CO)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.