LPM4870108 is a potent pan-Trk inhibitor, targeting wild-type and mutant variants with IC50 values of 0.2 nM for TrkC, 2.4 nM for TrkA, 3.5 nM for TrkAG595R, and 2.3 nM for TrkAG667C. It demonstrates selectivity for Trk over ALK, with an IC50 of 182 nM. LPM4870108 exhibits significant anti-tumor activity, making it a valuable tool for studying Trk-related oncogenic signaling pathways and developing targeted cancer therapies.
LPM4870108 is a potent pan-Trk inhibitor, targeting wild-type and mutant variants with IC50 values of 0.2 nM for TrkC, 2.4 nM for TrkA, 3.5 nM for TrkAG595R, and 2.3 nM for TrkAG667C. It demonstrates selectivity for Trk over ALK, with an IC50 of 182 nM. LPM4870108 exhibits significant anti-tumor activity, making it a valuable tool for studying Trk-related oncogenic signaling pathways and developing targeted cancer therapies.
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