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LPT99

APAF-1 Antagonist

LPT99 is a selective antagonist of apoptotic protease activating factor 1 (APAF-1), effectively inhibiting the activation of procaspase-9. This compound has been shown to suppress apoptosis induced by Cisplatin, making it a valuable tool in research related to chemotherapeutic-induced cellular responses. Additionally, LPT99 has demonstrated potential in mitigating Cisplatin-induced hearing loss in rat models, highlighting its relevance in neuroprotective studies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	1263477-83-3
Applications	APAF-1 Antagonist
Formula	C₃₁H₃₂Cl₂N₄O₄S
Molecular Weight	627.58
SMILES	O=C(CC1C(N(CCC2=CC=C(C=C2Cl)Cl)CC(N1CCC3=CC=CS3)=O)=O)NCCC4=CNC5=C4C=C(OC)C=C5

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.