Fig. 1 · Structure
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LS-102
Synoviolin Inhibitor
LS-102 is a selective inhibitor of synoviolin (Syvn1), an E3 ubiquitin ligase, effectively inhibiting its autoubiquitination with an IC50 of 35 μM. This compound demonstrates potential therapeutic applications in the treatment of rheumatoid arthritis by modulating synoviolin activity, which plays a critical role in inflammatory pathways. Researchers may utilize LS-102 to explore the biological functions of synoviolin and investigate novel therapeutic strategies for autoimmune disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1456891-34-1 |
| Applications | Synoviolin Inhibitor |
| Formula | C24H36N8O |
| Molecular Weight | 452.60 |
| SMILES | CCNCCN(CC)C1=NC(NC2=CC=C3N=COC3=C2)=NC(N[C@H](C4CCCCC4)C)=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.