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Biological Activity
LSN 3213128 is a selective, nonclassical, orally bioavailable antifolate with potent and specific inhibitory activity for aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT), with IC50 of 16 nM for AICARFT enzyme inhibiton and 19 nM in cells. Anti-tumor activity.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.42 mL | 122.11 mL | 244.22 mL |
| 0.5 mM | 4.88 mL | 24.42 mL | 48.84 mL |
| 1 mM | 2.44 mL | 12.21 mL | 24.42 mL |
| 5 mM | 0.49 mL | 2.44 mL | 4.88 mL |
*The above data is based on the productmolecular weight 409.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A19472 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1941211-99-9 |
| Formula | C17H16FN3O4S2 |
| M. Wt | 409.46 |
| Purity | >98% |
| Synonyms | LSN3213128, LSN-3213128 |
| SMILES | O=C1NC=CC2=C1C=C(NS(=O)(C3=CC=C(N4CC[C@@H](O)C4)S3)=O)C(F)=C2 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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