Fig. 1 · Structure
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LSN2463359
mGlu5 Modulator
LSN2463359 is a positive allosteric modulator of metabotropic glutamate receptor 5 (mGlu5), which plays a crucial role in synaptic transmission and plasticity. This compound has been shown to ameliorate behavioral responses in models utilizing competitive NMDA receptor antagonists and selectively improves reversal learning deficits in the MAM E17 neurodevelopmental model. Additionally, LSN2463359 serves as a click chemistry reagent, featuring an alkyne group that allows for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, facilitating biomedical applications in chemical biology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1401031-52-4 |
| Applications | mGlu5 Modulator |
| Formula | C16H15N3O |
| Molecular Weight | 265.31 |
| SMILES | O=C(C1=NC=C(C=C1)C#CC2=CC=NC=C2)NC(C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.