Fig. 1 · Structure
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LSN2814617
mGlu5 Modulator
LSN2814617 is a selective positive allosteric modulator of the metabotropic glutamate receptor 5 (mGlu5), exhibiting potent oral bioactivity with EC50 values of 52 nM in human and 42 nM in rat models. This compound has demonstrated a wake-promoting effect, making it a valuable tool in the investigation of neurological disorders. LSN2814617 is particularly relevant for research focused on schizophrenia and related conditions, where modulation of glutamatergic signaling may provide therapeutic insights.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1313498-17-7 |
| Applications | mGlu5 Modulator |
| Formula | C18H20FN5O |
| Molecular Weight | 341.38 |
| SMILES | FC1=CC=C(C=C1)C2=NOC([C@@H]3CC4=NN=C(N4CC3)C(C)(C)C)=N2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.