Fig. 1 · Structure
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LSN3353871
Lipoprotein(a) Inhibitor
LSN3353871 is a selective inhibitor of lipoprotein(a) (Lp(a)), targeting the Kringle IV domains KIV 5–8, KIV 7–8, and KIV 8, with dissociation constants (Kd) of 423 nM, 605 nM, and 756 nM, respectively. This compound disrupts the formation of Lp(a) with an IC50 value of 1.69 µM. LSN3353871 exhibits oral bioactivity, making it a valuable tool for research applications related to cardiovascular disease and lipoprotein metabolism.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2565657-20-5 |
| Applications | Lipoprotein(a) Inhibitor |
| Formula | C13H18ClNO2 |
| Molecular Weight | 255.74 |
| SMILES | OC([C@@H](CC1=CC=CC=C1)[C@@H]2CNCC2)=O.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.