LSP4-2022 is a selective orthosteric agonist of the metabotropic glutamate receptor subtype 4 (mGlu4) with an effective concentration (EC50) of 0.11 μM. This compound effectively inhibits neurotransmission in cerebellar slices derived from wild-type mice, demonstrating its functional specificity, as this effect is absent in mGlu4 receptor-knockout mice. Additionally, LSP4-2022 exhibits pro-depressant activity, making it a valuable tool for research in neuropharmacology and the study of mood disorders.
LSP4-2022 is a selective orthosteric agonist of the metabotropic glutamate receptor subtype 4 (mGlu4) with an effective concentration (EC50) of 0.11 μM. This compound effectively inhibits neurotransmission in cerebellar slices derived from wild-type mice, demonstrating its functional specificity, as this effect is absent in mGlu4 receptor-knockout mice. Additionally, LSP4-2022 exhibits pro-depressant activity, making it a valuable tool for research in neuropharmacology and the study of mood disorders.
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