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LT-626

PARP Inhibitor

LT-626 is a potent poly(ADP-ribose) polymerase (PARP) inhibitor, with an IC50 of 1.60 nM. This inhibitor effectively reduces cellular poly(ADP-ribose) synthesis, demonstrating an EC50 of 17.9 nM, and displays enhanced cytotoxicity in colorectal cancer cells with MRE11 mutations. Additionally, LT-626 exhibits synergistic effects when combined with chemotherapeutic agents such as Cisplatin, Oxaliplatin, and SN-38, making it a valuable tool for colorectal cancer research applications.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1207456-03-8
Applications	PARP Inhibitor
Formula	C₂₀H₁₅F₂N₅O
Molecular Weight	379.37
SMILES	CN1C([C@H]2C=3C4=C(N[C@@H]2C5=CC=C(F)C=C5)C=C(F)C=C4C(=O)NN3)=NC=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.