LT-626 is a potent poly(ADP-ribose) polymerase (PARP) inhibitor, with an IC50 of 1.60 nM. This inhibitor effectively reduces cellular poly(ADP-ribose) synthesis, demonstrating an EC50 of 17.9 nM, and displays enhanced cytotoxicity in colorectal cancer cells with MRE11 mutations. Additionally, LT-626 exhibits synergistic effects when combined with chemotherapeutic agents such as Cisplatin, Oxaliplatin, and SN-38, making it a valuable tool for colorectal cancer research applications.
LT-626 is a potent poly(ADP-ribose) polymerase (PARP) inhibitor, with an IC50 of 1.60 nM. This inhibitor effectively reduces cellular poly(ADP-ribose) synthesis, demonstrating an EC50 of 17.9 nM, and displays enhanced cytotoxicity in colorectal cancer cells with MRE11 mutations. Additionally, LT-626 exhibits synergistic effects when combined with chemotherapeutic agents such as Cisplatin, Oxaliplatin, and SN-38, making it a valuable tool for colorectal cancer research applications.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
