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Lu AF90103

Prodrug

Lu AF90103 is a methyl ester prodrug of compound 42d, designed to effectively penetrate the blood-brain barrier. The active compound, 42d, functions as a partial agonist of the GluN1/GluN2B complex, demonstrating 24% efficacy with an EC50 value of 78 nM. This reagent is crucial for exploring mechanisms underlying neuropsychiatric disorders and offers significant potential for advancing research in this field.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Partial Agonist
CAS Number	2577196-14-4
Applications	Prodrug
Formula	C₁₃H₁₅N₃O₃S
Molecular Weight	293.34
SMILES	CC1=C2C(C=C(S2)C(NC[C@@H](N)C(OC)=O)=O)=NC=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.