Fig. 1 · Structure
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Lubeluzole
Anti-ischemic Agent
Lubeluzole is an S-isomer of a benzothiazole derivative that acts as an anti-ischemic agent. It inhibits glutamate release and glutamate-activated nitric oxide synthesis while blocking voltage-gated sodium and calcium channels. Lubeluzole demonstrates neuroprotective and anti-ischemic effects, and has also shown potential in inhibiting the proliferation and invasion of cancer cells, as well as exhibiting chemosensitizing properties. Additionally, its antibacterial and anti-diarrheal activities make it relevant for research in cancer, infectious diseases, and neurological and cardiovascular disorders, including stroke and infectious diarrhea.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 144665-07-6 |
| Applications | Anti-ischemic Agent |
| Formula | C22H25F2N3O2S |
| Molecular Weight | 433.51 |
| SMILES | CN(C1CCN(CC1)C[C@H](O)COC2=CC(F)=C(C=C2)F)C3=NC4=CC=CC=C4S3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.