Fig. 1 · Structure
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Lucanthone
APE-1 Inhibitor
Lucanthone is a selective inhibitor of Apurinic endonuclease-1 (APE-1), targeting its endonuclease activity. This compound exhibits significant anti-tumor properties through its ability to enhance DNA damage sensitivity in cancer cells. Lucanthone has applications in cancer research, particularly in studies focused on DNA repair mechanisms and the therapeutic modulation of cellular responses to DNA-damaging agents.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 479-50-5 |
| Applications | APE-1 Inhibitor |
| Formula | C20H24N2OS |
| Molecular Weight | 340.48 |
| SMILES | O=C1C2=C(SC3=C1C=CC=C3)C(C)=CC=C2NCCN(CC)CC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.