Fig. 1 · Structure
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Lumasiran sodium
Glycolate Oxidase Inhibitor
Lumasiran sodium is a potent glycolate oxidase inhibitor that employs RNA interference (RNAi) mechanisms to effectively decrease hepatic oxalate production. By targeting this specific enzyme, Lumasiran sodium reduces urinary oxalate excretion, addressing the underlying cause of progressive kidney failure in patients with primary hyperoxaluria type 1 (PH1). This therapeutic approach offers significant promise for managing hyperoxalemia and its associated complications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1834612-06-4 |
| Applications | Glycolate Oxidase Inhibitor |
| Molecular Weight | 16340 (free acid) |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.