Fig. 1 · Structure
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Lumasiran
Glycolate Oxidase Inhibitor
Lumasiran is a small interfering RNA (siRNA) that specifically inhibits glycolate oxidase, leading to a reduction in hepatic oxalate production. By silencing the gene responsible for glycolate oxidase expression, Lumasiran effectively lowers the synthesis of oxalate, a toxic metabolite implicated in the clinical manifestations of Primary Hyperoxaluria type 1 (PH1). This compound is of particular interest in studies aimed at identifying therapeutic strategies for managing PH1 and related metabolic disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1834610-13-7 |
| Applications | Glycolate Oxidase Inhibitor |
| Molecular Weight | 16339.00 |
| Synonyms | ALN-G01 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.