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Lumateperone metabolite 1

Lumateperone Metabolite

Lumateperone metabolite 1 is a key metabolic derivative of Lumateperone, primarily targeting 5-HT2A receptors with high affinity (Ki = 0.54 nM). It exhibits dual action as a partial agonist at presynaptic D2 receptors and antagonist at postsynaptic D2 receptors (Ki = 32 nM), as well as modulation of dopamine D1 receptors. This compound is significant for research applications focused on neuropharmacology and the mechanisms of antipsychotic therapies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Partial Agonist
CAS Number	1469777-40-9
Applications	Lumateperone Metabolite
Formula	C₂₃H₂₈FN₃O
Molecular Weight	381.49
SMILES	OC(C1=CC=C(C=C1)F)CCCN2C[C@@]3([H])C4=CC=CC5=C4N(CCN5)[C@@]3([H])CC2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.