Fig. 1 · Structure
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Lupartumab Amadotin
Anti-C4.4A ADC
Lupartumab Amadotin is an antibody-drug conjugate (ADC) designed to target C4.4A (LYPD3). It comprises a fully human monoclonal antibody fused with a highly potent auristatin derivative through a stable noncleavable linker. This compound exhibits potent cytotoxic activity and is primarily utilized in research focused on non-small cell lung cancer, facilitating studies on targeted therapies and resistance mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1640972-00-4 |
| Applications | Anti-C4.4A ADC |
| Synonyms | BAY 1129980; Anti-C4.4a antibody-drug conjugates |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.