Fig. 1 · Structure
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LXRβ ligand 1
LXR Agonist
LXRβ ligand 1 is an agonist of the liver X receptor beta (LXRβ), exhibiting an EC50 of 57 μM and a Ki of 28 μM against human LXRβ. It engages in hydrogen bonding with His435, stabilizing the His-Trp activation switch and maintaining the ligand-binding domain in an agonist conformation. The tert-butyl moiety occupies a hydrophobic subpocket, while the phenyl moiety interacts via π-π stacking with Phe329. This compound serves as a foundational structure for the design of LXRβ modulators in research applications related to lipid metabolism and inflammation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 171049-41-5 |
| Applications | LXR Agonist |
| Formula | C14H20N2O2 |
| Molecular Weight | 248.32 |
| SMILES | O=C(N1CC2=CC(N)=CC=C2CC1)OC(C)(C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.