LY-228729

Catalog No.: A29768
5-HT1A Receptor Agonist
LY-228729 is a selective agonist of the 5-HT1A receptor, known for its significant effects on behavior. This compound has been shown to decrease rearing frequency and overall activity in rats during open field tests, as well as reduce immobility and enhance swimming time in forced swim tests. LY-228729 serves as a valuable tool in the investigation of neurological disorders and the modulation of serotonin-related pathways.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionLY-228729 is a selective agonist of the 5-HT1A receptor, known for its significant effects on behavior. This compound has been shown to decrease rearing frequency and overall activity in rats during open field tests, as well as reduce immobility and enhance swimming time in forced swim tests. LY-228729 serves as a valuable tool in the investigation of neurological disorders and the modulation of serotonin-related pathways.
Product Information
Catalog NumA29768
FormulaC18H25N3O
Molecular Weight299.41
CAS Number115994-31-5
SMILESNC(C1=CC=C2NC=C3C2=C1C[C@@H](N(CCC)CCC)C3)=O
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