Fig. 1 · Structure
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LY-272015 hydrochloride
5-HT2B Receptor Antagonist
LY-272015 hydrochloride is a specific antagonist of the 5-HT2B receptor. It effectively inhibits ERK2 phosphorylation triggered by serotonin (5-HT) or BW723C86, highlighting its role in modulating signaling pathways associated with serotonin receptors. Additionally, this compound demonstrates antihypertensive properties in models of DOCA-salt-induced hypertension, making it a valuable tool for research in cardiovascular and neuropharmacological studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 172895-15-7 |
| Applications | 5-HT2B Receptor Antagonist |
| Formula | C21H25ClN2O2 |
| Molecular Weight | 372.89 |
| SMILES | CC1=CC2=C(NC3=C2CCNC3CC4=CC=C(OC)C(OC)=C4)C=C1.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.