Fig. 1 · Structure
Documents & Downloads
LY 301875
AT1 Antagonist
LY 301875 is a potent and orally bioavailable angiotensin II receptor type 1 (AT1) antagonist, exhibiting a pKB value of 9.6. This compound effectively inhibits the AT1 receptor, playing a pivotal role in regulating blood pressure and cardiovascular function. It is valuable for research applications related to hypertension, cardiovascular diseases, and the exploration of angiotensin signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 154668-27-6 |
| Applications | AT1 Antagonist |
| Formula | C31H36N4O10S |
| Molecular Weight | 656.70 |
| SMILES | CCCCCC[C@@H](N1C=C(N=C1)NC(C2=C(C=CC=C2)S(=O)(O)=O)=O)C(N3[C@@H](C[C@@H](C3)OC4=CC=C(C=C4)CC(O)=O)C(O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.